Publications

Partial list of Publications (2020-2024)

  • Fu A, Luo Z, Ziv T, Bi X, Lulu-Shimron C, Cohen-Kaplan V, Ciechanover A. Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF4. Proc Natl Acad Sci U S A. 2024 Oct 2;121(43):e2414377121.
  • Livneh I, Fabre B, Goldhirsh G, Lulu C, Zinger A, Shammai Vainer Y, Kaduri M, Dahan A, Ziv T, Schroeder A, Ben-Neriah Y, Zohar Y, Cohen-Kaplan V, Ciechanover A. Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive. Cell Death Differ. 2024 Oct;31(10):1242-1254.
  • Haykin H, Avishai E, Krot M, Ghiringhelli M, Reshef M, Abboud Y, Melamed S, Merom S, Boshnak N, Azulay-Debby H, Ziv T, Gepstein L, Rolls A. Reward system activation improves recovery from acute myocardial infarction. Nat Cardiovasc Res. 2024 Jul;3(7):841-856.
  • Haddad R, Sadeh O, Ziv T, Erlich I, Haimovich-Caspi L, Shemesh A, van der Velden J, Kehat I. Localized translation and sarcomere maintenance requires ribosomal protein SA in mice. J Clin Invest. 2024 May 14;134(13):e174527.
  • Salti T, Braunstein I, Haimovich Y, Ziv T, Benhar M. Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress. Redox Biol. 2024 Jun;72:103125.
  • Kaplan B, Goldis R, Ziv T, Dori A, Magen H, Simon AJ, Volkov A, Maor E, Arad M. Amyloid Typing in Cardiac Amyloidosis Using Western Blotting. Isr Med Assoc J. 2024 Mar;26(3):149-156
  • Nadel G, Yao Z, Hacohen-Lev-Ran A, Wainstein E, Maik-Rachline G, Ziv T, Naor Z, Admon A, Seger R. Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis. Cell Commun Signal. 2024 Feb 28;22(1):154.
  • Shakarchy A, Zarfati G, Hazak A, Mealem R, Huk K, Ziv T, Avinoam O, Zaritsky Machine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion. Mol Syst Biol. 2024 Mar;20(3):217-241.
  • Goldis R, Kaplan B, Arad M, Dispenzieri A, Dasari S, Kukuy OL, Simon AJ, Dori A, Shavit-Stein E, Ziv T, Murray D, Kourelis T, Gertz MA, Dominissini D, Magen H, Muchtar E. Amino acid sequence homology of monoclonal serum free light chain dimers and tissue deposited light chains in AL amyloidosis: a pilot study. Clin Chem Lab Med. 2023 Sep 26;62(3):464-471.
  • Livneh I, Cohen-Kaplan V, Fabre B, Abramovitch I, Lulu C, Nataraj NB, Lazar I, Ziv T, Yarden Y, Zohar Y, Gottlieb E, Ciechanover A. Regulation of nucleo- cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress. Mol Cell. 2023 Sep 21;83(18):3333-3346.e5.
  • Mandelbaum N, Zhang L, Carasso S, Ziv T, Lifshiz-Simon S, Davidovich I, Luz I, Berinstein E, Gefen T, Cooks T, Talmon Y, Balskus EP, Geva-Zatorsky N. Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects. NPJ Biofilms Microbiomes. 2023 Jun 3;9(1):30.
  • Sweetat S, Nitzan K, Suissa N, Haimovich Y, Lichtenstein M, Zabit S, Benhamron S, Akarieh K, Mishra K, Barasch D, Saada A, Ziv T, Kakhlon O, Lorberboum-Galski H, Rosenmann H. The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver-Serum-Brain Response. Cells. 2023 Mar 24;12(7):1006.
  • Hazan Ben-Menachem R, Lintzer D, Ziv T, Das K, Rosenhek-Goldian I, Porat Z, Ben Ami Pilo H, Karniely S, Saada A, Regev-Rudzki N, Pines O. Mitochondrial-derived vesicles retain membrane potential and contain a functional ATP synthase. EMBO Rep. 2023 May 4;24(5):e56114
  • Cohen-Gulkar M, David A, Messika-Gold N, Eshel M, Ovadia S, Zuk-Bar N, Idelson M, Cohen-Tayar Y, Reubinoff B, Ziv T, Shamay M, Elkon R, Ashery-Padan R. The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. PLoS Biol. 2023 Jan 17;21(1):e3001924.
  • Cohen LD, Ziv T, Ziv NE. Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points. Front Mol Neurosci. 2022 Dec 13;15:1038614
  • Sheinboim D, Parikh S, Manich P, Markus I, Dahan S, Parikh R, Stubbs E, Cohen G, Zemser-Werner V, Bell RE, Ruiz SA, Percik R, Brenner R, Leibou S, Vaknine H, Arad G, Gerber Y, Keinan-Boker L, Shimony T, Bikovski L, Goldstein N, Constantini K, Labes S, Mordechai S, Doron H, Lonescu A, Ziv T, Nizri E, Choshen G, Eldar-Finkelman H, Tabach Y, Helman A, Ben-Eliyahu S, Erez N, Perlson E, Geiger T, Ben-Zvi D, Khaled M, Gepner Y, Levy C. An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination. Cancer Res. 2022 Nov 15;82(22):4164-4178.
  • Abu Hariri H, Braunstein I, Salti T, Glaser F, Gefen T, Geva-Zatorsky N, Ziv T, Benhar M. Global Thiol Proteome Analysis Provides Novel Insights into the Macrophage Inflammatory Response and Its Regulation by the Thioredoxin System. Antioxid Redox Signal. 2022 Oct 18.
  • Mann G, Sulkshane P, Sadhu P, Ziv T, Glickman MH, Brik A. Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. Molecules. 2022 Jul 29;27(15):4867.
  • Parikh S, Parikh R, Michael K, Bikovski L, Barnabas G, Mardamshina M, Hemi R, Manich P, Goldstein N, Malcov-Brog H, Ben-Dov T, Glaich O, Liber D, Bornstein Y, Goltseker K, Ben-Bezalel R, Pavlovsky M, Golan T, Spitzer L, Matz H, Gonen P, Percik R, Leibou L, Perluk T, Ast G, Frand J, Brenner R, Ziv T, Khaled M, Ben-Eliyahu S, Barak S, Karnieli-Miller O, Levin E, Gepner Y, Weiss R, Pfluger P, Weller A, Levy C. Food-seeking behavior is triggered by skin ultraviolet exposure in males. Nat Metab. 2022 Jul;4(7):883-900.
  • Abou Karam P, Rosenhek-Goldian I, Ziv T, Ben Ami Pilo H, Azuri I, Rivkin A, Kiper E, Rotkopf R, Cohen SR, Torrecilhas AC, Avinoam O, Rojas A, Morandi MI, Regev-Rudzki N. Malaria parasites release vesicle subpopulations with signatures of different destinations. EMBO Rep. 2022 Jul 5;23(7).
  • Mukherjee S, Maddalena M, Lü Y, Martinez S, Nataraj NB, Noronha A, Sinha S, Teng K, Cohen-Kaplan V, Ziv T, Arandkar S, Hassin O, Chatterjee R, Pirona AC, Shreberk-Shaked M, Gershoni A, Aylon Y, Elazar Z, Yarden Y, Schramek D, Oren M. Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins. Proc Natl Acad Sci U S A. 2022 Apr 26;119(173).
  • Goldhirsh G, Kravtsova-Ivantsiv Y, Satish G, Ziv T, Brik A, Ciechanover A. A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49).
  • Korsensky L, Chorev D, Saleem H, Heller-Japheth R, Rabinovitz S, Haif S, Dahan N, Ziv T, Ron D. Regulation of stability and inhibitory activity of the tumor suppressor SEF through casein-kinase II-mediated phosphorylation. Cell Signal. 2021 Oct;86:110085.
  • González-López MDC, Jijón-Moreno S, Dautt-Castro M, Ovando-Vázquez C, Ziv T, Horwitz BA, Casas-Flores S. Secretome Analysis of Arabidopsis-Trichoderma atroviride Interaction Unveils New Roles for the Plant Glutamate:Glyoxylate Aminotransferase GGAT1 in Plant Growth Induced by the Fungus and Resistance against Botrytis cinerea. Int J Mol Sci. 2021 Jun 24;22(13):6804.
  • Shaihov-Teper O, Ram E, Ballan N, Brzezinski RY, Naftali-Shani N, Masoud R, Ziv T, Lewis N, Schary Y, Levin-Kotler LP, Volvovitch D, Zuroff EM, Amunts S, Regev-Rudzki N, Sternik L, Raanani E, Gepstein L, Leor J. Extracellular Vesicles from Epicardial Fat Facilitate Atrial Fibrillation. Circulation. 2021 Jun 22;143(25):2475-2493. doi: 10.1161/CIRCULATIONAHA.120.052009.
  • Dekel E, Yaffe D, Rosenhek-Goldian I, Ben-Nissan G, Ofir-Birin Y, Morandi MI, Ziv T, Sisquella X, Pimentel MA, Nebl T, Kapp E, Ohana Daniel Y, Karam PA, Alfandari D, Rotkopf R, Malihi S, Temin TB, Mullick D, Revach OY, Rudik A, Gov NS, Azuri I, Porat Z, Bergamaschi G, Sorkin R, Wuite GJL, Avinoam O, Carvalho TG, Cohen SR, Sharon M, Regev-Rudzki N. 20S proteasomes secreted by the malaria parasite promote its growth. Nat Commun. 2021 Feb 19;12(1):1172.
  • Richard S, Gross L, Fischer J, Bendalak K, Ziv T, Urim S, Choder M. Numerous Post-translational Modifications of RNA Polymerase II Subunit Rpb4/7 Link Transcription to Post-transcriptional Mechanisms. Cell Rep. 2021 Jan 12;34(2):108578.
  • Udasin RG, Gottfried Y, Fabre B, Bercovich B, Ziv T, Ciechanover A. The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation. Biochem Biophys Res Commun. 2020 Sep 12:S0006-291X(20)31690-9.
  • Sulkshane P, Duek I, Ram J, Thakur A, Reis N, Ziv T, Glickman MH. Inhibition of proteasome reveals basal mitochondrial ubiquitination. J Proteomics. 2020 Oct 30;229:103949.
  • Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, Yu-Taeger L, Ziv T, Kwon YT, Riess O, Phuc Nguyen HH, Ziv NE, Ciechanover A. Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18661-18669. doi: 10.1073/pnas.2007667117.
  • Braunstein I, Engelman R, Yitzhaki O, Ziv T, Galardon E, Benhar M. Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation. J Biol Chem. 2020 Mar 13;295(11):3590-3600.
  • Raldúa D, Casado M, Prats E, Faria M, Puig-Castellví F, Pérez Y, Alfonso I, Hsu CY, Arick Ii MA, Garcia-Reyero N, Ziv T, Ben-Lulu S, Admon A, Piña B. Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain. Sci Rep. 2020 Jan 15;10(1):312.